Association Study of FYN Gene Polymorphism and Methamphetamine Use Disorder

Fyn kinase belongs to the Src family of tyrosine kinases and phosphorylates NMDA receptor subunits. The Fyn kinase gene, FYN, has been considered to be involved in the pathophysiologies of neuropsychiatric diseases. We examined three polymorphisms, rs706895, rs3730353, and rs6916861, of the FYN gene in 250 patients with methamphetamine use disorder and 275 controls. There were no significant differences between the patients and controls in genotype or allele distribution. In haplotype association analyses, the C-T haplotype at rs3730353-rs6916861 showed a significant association with methamphetamine use disorder. We also analyzed the clinical phenotypes of methamphetamine use disorder. Rs3730353 and rs6916861 showed a significant association with age at first consumption in genotype and allele distributions, and multiplesubstance abuse status in the genotype distribution. The present study suggests that genetic variation of the FYN gene may be related to the severity of methamphetamine use disorder in a Japanese population.